LCAP rabbit pAb

This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

Product Specifications

Background

UniProt

Q9UIQ6

Swiss Prot

Q9UIQ6

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized peptide derived from part region of human protein AA range: 705-755

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight

112kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

112kD

Fragment

IgG

Subcellular Location

Cell membrane ; Single-pass type II membrane protein . In brain only the membrane-bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases.; [Leucyl-cystinyl aminopeptidase, pregnancy serum form]: Secreted. During pregnancy serum levels are low in the first trimester, rise progressively during the second and third trimester and decrease rapidly after parturition.