SARM1 rabbit pAb

Caution: Was initially reported to contain ARM repeats (PubMed: 11386760). Such repeats are however not predicted by any detection method. function: Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation. similarity: Contains 1 TIR domain. similarity: Contains 2 SAM (sterile alpha motif) domains. subunit: Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function. tissue specificity: Predominantly expressed in kidney and liver. Expressed at lower level in placenta.