BEX3 rabbit pAb
Domain: The nuclear export signal is required for export from the nucleus and the interactions with itself and p75NTR/NGFR. function: May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases. miscellaneous: Binds transition metals. PTM: Ubiquitinated. Degraded by the proteasome. similarity: Belongs to the BEX family. subcellular location: Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria. subunit: Self-associates. Interacts with 14-3-3 epsilon (YWHAE). Interacts with DIABLO/SMAC (By similarity). Binds to the DEATH domain of p75NTR/NGFR. tissue specificity: Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver.
Product Specifications
Background
UniProt
Q00994
Swiss Prot
Q00994
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 1-80
Target
BEX3
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
12kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
12kD
Fragment
IgG
Subcellular Location
Nucleus. Cytoplasm. Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria (By similarity) . .
Gene ID (Human)
27018
Available Sizes
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