GBLP rabbit pAb

Domain: The WD repeats domain 5 mediates interaction with TRIM63. function: Seems to bind protein kinase C acting as an intracellular receptor to anchor the activated PKC to the cytoskeleton. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and ITGB1, serves as a platform for SRC activation or inactivation. May play an important role in the developing brain and neuronal differentiation. similarity: Belongs to the WD repeat G protein beta family. similarity: Contains 7 WD repeats. subcellular location: Located on plasma membrane of neuroblastoma NMB7 cells. subunit: Binds SLC9A3R1. Forms a ternary complex with TRIM63 and PRKCE. Interacts with HABP4 and KRT1.

Product Specifications

Background

Domain:The WD repeats domain 5 mediates interaction with TRIM63., function:Seems to bind protein kinase C acting as an intracellular receptor to anchor the activated PKC to the cytoskeleton. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and ITGB1, serves as a platform for SRC activation or inactivation. May play an important role in the developing brain and neuronal differentiation., similarity:Belongs to the WD repeat G protein beta family., similarity:Contains 7 WD repeats., subcellular location:Located on plasma membrane of neuroblastoma NMB7 cells., subunit:Binds SLC9A3R1. Forms a ternary complex with TRIM63 and PRKCE. Interacts with HABP4 and KRT1.

UniProt

P63244

Swiss Prot

P63244

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized peptide derived from part region of human protein

Target

GBLP

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Buffer

-20°C/1 year

Molecular Weight

34kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

34kD

Fragment

IgG

Subcellular Location

Cell membrane ; Peripheral membrane protein. Cytoplasm . Cytoplasm, perinuclear region . Nucleus . Perikaryon . Cell projection, dendrite . Cell projection, phagocytic cup . Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1 (PubMed:17956333) . Also associated with the membrane in oncogene-transformed cells (PubMed:11884618) . PKC activation induces translocation from the perinuclear region to the cell periphery (PubMed:11279199) . In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei (By similarity) . Localized to phagocytic cups following infection by Y.pestis (PubMed:21347310) . .