IL18 rabbit pAb

The protein encoded by this gene is a proinflammatory Cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011],

Product Specifications

Background

The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

UniProt

Q14116

Swiss Prot

Q14116

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized peptide derived from part region of human protein

Target

IL18

Clonality

Polyclonal

Source

Rabbit

Applications

WB IF; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000 Not yet tested in other applications.

Buffer

-20°C/1 year

Molecular Weight

21kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

21kD

Fragment

IgG

Subcellular Location

Cytoplasm . Secreted . The precursor is cytosolic (PubMed:33883744) . In response to inflammasome-activating signals, cleaved and secreted (PubMed:33883744) . Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744) . In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (PubMed:33883744) . The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (PubMed:32272059) . .