SIK2 rabbit pAb

Catalytic activity: ATP + a protein = ADP + a phosphoprotein. Cofactor: Magnesium. enzyme regulation: Activated by phosphorylation on Thr-175 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39. function: Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily. similarity: Contains 1 protein kinase domain. similarity: Contains 1 UBA domain. subunit: Interacts with and phosphorylates TORC2/CRTC2.