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CC14B rabbit pAb

Cell division cycle 14B (CDC14B) Homo sapiens The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008],

Product Specifications

Background

Cell division cycle 14B (CDC14B) Homo sapiens The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

UniProt

O60729

Swiss Prot

O60729

Reactivity

Human; Mouse

Immunogen

Synthesized peptide derived from part region of human protein AA range: 407-457

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight

54kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

54kD

Fragment

IgG

Subcellular Location

Nucleus, nucleolus. Nucleus, nucleoplasm. Following DNA damage, translocates from the nucleolus to the nucleoplasm and interacts with FZR1/CDH1.

Gene ID (Human)

8555

Available Sizes

Curated Selection

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