KDM3B rabbit pAb

Cofactor: Binds 1 Fe (2+) ion per subunit. Domain: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors. function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. miscellaneous: Its gene is located in the 5q region of the genome which is deleted in del (5q) interstitial deletion, a frequent deletion found in myeloid leukemias and myelodysplasias, suggesting that it may be a good candidate for the del (5q) tumor suppressor gene. similarity: Belongs to the JHDM2 histone demethylase family. similarity: Contains 1 JmjC domain. tissue specificity: Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver.