CYFP1 rabbit pAb

Function: Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA. similarity: Belongs to the CYFIP family. subcellular location: Highly expressed in the perinuclear region. Enriched in synaptosomes, membrane ruffles and at the tips of lamellipodia. subunit: Interacts with the active GTP-bound form of RAC1. Interacts with FMR1/FMRP but does not bind to related proteins FXR1 or FXR2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2 (By similarity). Interacts through its C-terminus with the C-terminus of DPYSL2/CRMP2 which is necessary for DPYSL2-induced axon outgrowth.

Product Specifications

Background

Function:Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA., similarity:Belongs to the CYFIP family., subcellular location:Highly expressed in the perinuclear region. Enriched in synaptosomes, membrane ruffles and at the tips of lamellipodia., subunit:Interacts with the active GTP-bound form of RAC1. Interacts with FMR1/FMRP but does not bind to related proteins FXR1 or FXR2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2 (By similarity) . Interacts through its C-terminus with the C-terminus of DPYSL2/CRMP2 which is necessary for DPYSL2-induced axon outgrowth.

UniProt

Q7L576

Swiss Prot

Q7L576

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized peptide derived from human protein . at AA range: 980-1060

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight

137kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

137kD

Fragment

IgG

Subcellular Location

Cytoplasm . Cytoplasm, perinuclear region . Cell projection, lamellipodium . Cell projection, ruffle . Cell junction, synapse, synaptosome . Highly expressed in the perinuclear region (By similarity) . Enriched in synaptosomes (By similarity) . Also enriched in membrane ruffles and at the tips of lamellipodia (By similarity) . .