CUL7 rabbit pAb

The protein encoded by this gene is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009],

Product Specifications

Background

The protein encoded by this gene is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1) . Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

UniProt

Q14999

Swiss Prot

Q14999

Reactivity

Human; Mouse

Immunogen

Synthesized peptide derived from human protein . at AA range: 1570-1650

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight

186kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

186kD

Fragment

IgG

Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Golgi apparatus. Colocalizes with FBXW8 at the Golgi apparatus in neurons; localization to Golgi is mediated by OBSL1. During mitosis, localizes to the mitotic apparatus (PubMed:24793695) . CCDC8 is required for centrosomal location (PubMed:24793695) . .