3BP1 rabbit pAb

Function: Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac. sequence Caution: Translated as Cys. similarity: Contains 1 BAR domain. similarity: Contains 1 Rho-GAP domain.

Product Specifications

Background

Function:Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac., sequence caution:Translated as Cys., similarity:Contains 1 BAR domain., similarity:Contains 1 Rho-GAP domain.

UniProt

Q9Y3L3

Swiss Prot

Q9Y3L3

Reactivity

Human; Mouse

Immunogen

Synthesized peptide derived from human protein . at AA range: 170-250

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight

77kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

77kD

Fragment

IgG

Subcellular Location

Cell projection . Cell junction, tight junction . Cell junction, adherens junction . Cell projection, phagocytic cup . Nucleus . Cytoplasm, cytosol . Localizes at the leading edge of migrating cells (PubMed:21658605, PubMed:24841563) . Accumulation at forming phagocytic cups is PI3 kinase/PI3K-dependent and is specific for sites of large particles engagement and their phosphatidylinositol 3,4,5-triphosphate membrane content (PubMed:26465210) . .