PLK4 rabbit pAb

This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Nucleus, nucleolus . Cleavage furrow . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Associates with centrioles throughout the cell cycle. According to PubMed:16244668, it is not present at cleavage furrows.