RPGF6 rabbit pAb

Function: Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Contains 1 cyclic nucleotide-binding domain. similarity: Contains 1 N-terminal Ras-GEF domain. similarity: Contains 1 PDZ (DHR) domain. similarity: Contains 1 Ras-associating domain. similarity: Contains 1 Ras-GEF domain. subcellular location: Upon binding to M-Ras, it translocates to the plasma membrane. subunit: Interacts with the second PDZ domain of human PTP1e. tissue specificity: Isoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is barely detectable in skeletal muscle, kidney and pancreas.