RPGF4 rabbit pAb

Domain: The DEP domain is involved in membrane localization independent from regulation by cAMP. Domain: The N-terminal nucleotide phosphate binding region cAMP 1 has a much lower affinity for cAMP as compared to cAMP 2. function: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2. similarity: Contains 1 DEP domain. similarity: Contains 1 N-terminal Ras-GEF domain. similarity: Contains 1 Ras-GEF domain. similarity: Contains 2 cyclic nucleotide-binding domains. subunit: Interacts with RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A. tissue specificity: Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels.