PPIG rabbit pAb

Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0). Domain: The RS domain is required for the interaction with the phosphorylated C-terminal domain of RNA polymerase II. enzyme regulation: Cyclosporin A (CsA)-sensitive. function: PPIases accelerate the folding of proteins. function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Belongs to the cyclophilin-type PPIase family. similarity: Contains 1 PPIase cyclophilin-type domain. subcellular location: Colocalizes with RNA splicing factors at nuclear speckles. subunit: Interacts with CLK1, PNN and with the phosphorylated C-terminal domain of RNA polymerase II. tissue specificity: Ubiquitous.