DCTN4 rabbit pAb

Function: Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. similarity: Belongs to the dynactin subunit 4 family. subcellular location: Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin. Overexpression does not disrupt microtubule organization or the integrity of the Golgi but does cause both cytosolic and nuclear distribution, suggesting that this polypeptide may be targeted to the nucleus at very high expression levels. subunit: Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10 (By similarity). Binds directly to the ACTR1A subunit of dynactin.

Product Specifications

Background

Function:Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton., similarity:Belongs to the dynactin subunit 4 family., subcellular location:Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin. Overexpression does not disrupt microtubule organization or the integrity of the Golgi but does cause both cytosolic and nuclear distribution, suggesting that this polypeptide may be targeted to the nucleus at very high expression levels., subunit:Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10 (By similarity) . Binds directly to the ACTR1A subunit of dynactin.

UniProt

Q9UJW0

Swiss Prot

Q9UJW0

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from part region of human protein

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight

50kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

50kD

Fragment

IgG

Subcellular Location

Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, stress fiber . Cytoplasm, cell cortex . Cytoplasm, myofibril, sarcomere . Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin (PubMed:10671518) . Overexpression in cultured mammalian cells revealed colocalization with cortical actin, stress fibers, and focal adhesion sites, sites of potential interaction between microtubules and the cell cortex (By similarity) . In skeletal muscles, costamere localization requires the presence of ANK2 (By similarity) . .