ITBP2 rabbit pAb

Domain: The tail domain binds to the cytoplasmic domain of both integrin beta-1a and beta-1d isoforms. The presence of Ca (2+) ions does not prevent binding of a fragment consisting of the second cysteine rich repeat and the tail domain but prevents the binding of the full-length protein. function: May play a role during maturation and/or organization of muscles cells. similarity: Contains 1 CS domain. similarity: Contains 2 CHORD domains. subunit: Interacts with beta-1 integrin subunit. This interaction is regulated by divalent cations, and it occurs only in absence of calcium. tissue specificity: Expressed in skeletal and cardiac muscles but not in other tissues.