RXRA rabbit pAb

Retinoid X receptor alpha (RXRA) Homo sapiens Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014],

Product Specifications

Background

UniProt

P19793

Swiss Prot

P19793

Reactivity

Human; Mouse; Rat; Bovine

Immunogen

Synthesized peptide derived from human protein . at AA range: 200-280

Target

RXRA

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Buffer

-20°C/1 year

Molecular Weight

50kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

50kD

Fragment

IgG

Subcellular Location

Nucleus . Cytoplasm . Mitochondrion . Localization to the nucleus is enhanced by vitamin D3 (PubMed:15509776) . Nuclear localization may be enhanced by the interaction with heterodimerization partner VDR (PubMed:12145331) . Translocation to the mitochondrion upon interaction with NR4A1 (PubMed:17761950, PubMed:15509776) . Increased nuclear localization upon pulsatile shear stress (PubMed:28167758) . .