CREB3 rabbit pAb

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined. [provided by RefSeq, Nov 2009],

Product Specifications

Background

Product Name Alternative

Cyclic AMP-responsive element-binding protein 3 (CREB-3) (cAMP-responsive element-binding protein 3) (Leucin zipper proitein) (Luman) (Transcription factor LZIP-alpha) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3 (N-terminal Luman) (Transcriptionally active form) ]

UniProt

O43889

Swiss Prot

O43889

Reactivity

Human; Mouse; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from the Internal region of human CREB3. AA range:151-200

Target

CREB3

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000, ELISA 1:10000-20000

Buffer

-20°C/1 year

Molecular Weight

50kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

50kD

Fragment

IgG

Subcellular Location

[Isoform 1]: Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Golgi apparatus . Colocalizes with HCFC1 in neuronal cell bodies of the trigeminal ganglia (PubMed:10623756) . Colocalizes with DCSTAMP in the ER membrane of immature dendritic cell (DC) (PubMed:20546900) . Colocalizes with CANX, CCR1, HCFC1 in the ER membrane (PubMed:10623756) . .; [Isoform 2]: Nucleus . Cytoplasm . Predominantly in the nucleus (PubMed:19779205) . Not associated with membranes (PubMed:19779205) . .; [Processed cyclic AMP-responsive element-binding protein 3]: Nucleus. Upon RIP activation the transcriptional active processed cyclic AMP-responsive element-binding protein 3 form translocates into the nucleus. Detected in the nucleus upon dendritic cell maturation and RIP activation. Colocalizes w