MELK rabbit pAb

Catalytic activity: ATP + a protein = ADP + a phosphoprotein. function: Phosphorylates ZNF622 and may contribute to its redirection to the nucleus. May be involved in the inhibition of spliceosome assembly during mitosis. PTM: Autophosphorylated. Thr-478 phosphorylation during mitosis promotes interaction with PPP1R8. similarity: Belongs to the protein kinase superfamily. similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. similarity: Contains 1 KA1 (kinase-associated) domain. similarity: Contains 1 protein kinase domain. subunit: Interacts with ZNF622 and PPP1R8. tissue specificity: Expressed in placenta, kidney, thymus, testis, ovary and intestine.