Tuberin (phospho Tyr1571) rabbit pAb
Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
Product Specifications
Background
Synonyms
TSC2; TSC4; Tuberin; Tuberous sclerosis 2 protein
Gene ID
7249
UniProt
P49815
Cellular Locus
Cytoplasm. Membrane; Peripheral membrane protein. At steady state found in association with membranes.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human TSC2 around the phosphorylation site of Tyr1571. AA range:1537-1586
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, IHC, IF, ELISA
Validated Applications
WB,IHC,IF,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Molecular Weight
170kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES7450-1.pdf
Observed Molecular Weight
170 kD
Subcellular Location
Cytoplasm. Membrane; Peripheral membrane protein. At steady state found in association with membranes.
Other Product Names
TSC2; TSC4; Tuberin; Tuberous sclerosis 2 protein
Gene ID (Human)
7249
SwissProt (Human)
P49815
Available Sizes
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