TLE2 rabbit pAb
Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. similarity: Belongs to the WD repeat Groucho/TLE family. similarity: Contains 6 WD repeats. subunit: Homooligomer and heterooligomer with other family members. Binds LEF1, TCF7, TCF7L1, TCF7L2, UTY, HES1 and HES5. tissue specificity: In all tissues examined, mostly in heart, brain, and muscle.
Product Specifications
Background
UniProt
Q04725
Swiss Prot
Q04725
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human TLE2. AA range:211-260
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
110kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
110kD
Fragment
IgG
Subcellular Location
Nucleus.
Other Product Names
TLE2; Transducin-like enhancer protein 2; Enhancer of split groucho-like protein 2; ESG2
Gene ID (Human)
7089
Available Sizes
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