Tie-1 rabbit pAb
This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011],
Product Specifications
Background
Synonyms
TIE1; TIE; Tyrosine-protein kinase receptor Tie-1
Gene ID
7075
UniProt
P35590
Cellular Locus
Cell membrane ; Single-pass type I membrane protein.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human TIE1. AA range:851-900
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, IHC, IF, ELISA
Validated Applications
WB,IHC,IF,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
IHC-p: 100-300.Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
130kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES7394-1.pdf
Observed Molecular Weight
130 kD
Subcellular Location
Cell membrane ; Single-pass type I membrane protein .
Other Product Names
TIE1; TIE; Tyrosine-protein kinase receptor Tie-1
Gene ID (Human)
7075
SwissProt (Human)
P35590
Available Sizes
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