Stat4 (phospho Tyr693) rabbit pAb
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011],
Product Specifications
Background
UniProt
Q14765
Swiss Prot
Q14765
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized phospho-peptide around the phosphorylation site of human Stat4 (phospho Tyr693)
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
85kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
85kD
Fragment
IgG
Subcellular Location
Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
Other Product Names
STAT4; Signal transducer and activator of transcription 4
Gene ID (Human)
6775
Available Sizes
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