ACE2 rabbit pAb

Angiotensin I converting enzyme 2 (ACE2) Homo sapiens The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008],

Product Specifications

Background

Product Name Alternative

ACE2; Angiotensin-converting enzyme 2; ACE-related carboxypeptidase; Angiotensin-converting enzyme homolog; ACEH; Metalloprotease MPROT15

UniProt

Q9BYF1

Swiss Prot

Q9BYF1

Reactivity

Human; Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human ACE2. AA range:416-465

Target

ACE2

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Buffer

-20°C/1 year

Molecular Weight

90kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

90kD

Fragment

IgG

Subcellular Location

[Processed angiotensin-converting enzyme 2]: Secreted .; Cell membrane ; Single-pass type I membrane protein . Cytoplasm . Cell projection, cilium . Apical cell membrane . Detected in both cell membrane and cytoplasm in neurons. .; [Isoform 2]: Apical cell membrane .