JAB-3312
Product Specifications
UNSPSC Description
JAB-3312 is an orally effective anticancer phosphatase SHP2 inhibitor (IC50: 1.9 nM) with anti-cancer activity. JAB-3312 has good tolerability and significantly induced tumor regression in a KYSE-520 mouse xenograft model[1].
Target Antigen
SHP2
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/jab-3312.html
Smiles
N[C@H](C(C=CC=N1)=C1C2)C2(CC3)CCN3C(N=C4)=CN=C4SC5=C(Cl)C(N)=NC=C5
Molecular Weight
439.96
References & Citations
[1]Discovery of JAB-3312, a Potent SHP2 Allosteric Inhibitor for Cancer Treatment
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161952/JAB-3312-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161952/
Clinical Information
Phase 3
CAS Number
2245082-05-5
Available Sizes
Curated Selection
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