BCAS3 rabbit pAb

Developmental stage: Fetal. Disease: A chromosomal aberration involving BCAS3 may be a cause of breast cancer. Translocation t (17;20) (q23;q13) with BCAS4. similarity: Belongs to the WD repeat BCAS3 family. similarity: Contains 3 WD repeats. tissue specificity: Stomach, liver, lung, kidney, prostate, testis, thyroid gland, adrenal gland, brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leucocyte and mammary epithelial cells. Overexpressed in most breast cancer cell lines.

Product Specifications

Background

Developmental stage:Fetal., disease:A chromosomal aberration involving BCAS3 may be a cause of breast cancer. Translocation t (17;20) (q23; q13) with BCAS4., similarity:Belongs to the WD repeat BCAS3 family., similarity:Contains 3 WD repeats., tissue specificity:Stomach, liver, lung, kidney, prostate, testis, thyroid gland, adrenal gland, brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leucocyte and mammary epithelial cells. Overexpressed in most breast cancer cell lines.

Product Name Alternative

BCAS3; Breast carcinoma-amplified sequence 3; GAOB1

UniProt

Q9H6U6

Swiss Prot

Q9H6U6

Reactivity

Human; Mouse

Immunogen

Synthesized peptide derived from BCAS3 . at AA range: 660-740

Target

BCAS3

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

Buffer

-20°C/1 year

Molecular Weight

100kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

100kD

Fragment

IgG

Subcellular Location

Nucleus . Cytoplasm . Cytoplasm, cytoskeleton . Preautophagosomal structure . Localizes in the cytoplasm in stationary cells. Translocates from the cytoplasm to the leading edge in motile cells. Colocalizes with microtubules and intermediate filaments in both stationary and motile cells (By similarity) . Associates with chromatin. Recruited to estrogen receptor-induced promoters in a PELP1-dependent manner. The BCAS3:PHAF1 complex is recruited to the preautophagosomal structures adjacent to the damaged mitochondria upon mitophagy in a PRKN-PINK1 dependent manner (PubMed:33499712) . .