Arkadia rabbit pAb
Ring finger protein 111 (RNF111) Homo sapiens The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012],
Product Specifications
Background
Product Name Alternative
RNF111; E3 ubiquitin-protein ligase Arkadia; RING finger protein 111
UniProt
Q6ZNA4
Swiss Prot
Q6ZNA4
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human RNF111. AA range:901-950
Target
Arkadia
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
110kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
110kD
Fragment
IgG
Subcellular Location
Nucleus . Cytoplasm . Nucleus, PML body . Upon TGF-beta treatment, translocates from nucleus to cytosol. .
Other Product Names
RNF111; E3 ubiquitin-protein ligase Arkadia; RING finger protein 111
Gene ID (Human)
54778
Available Sizes
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