MARCH5 rabbit pAb

MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al. 2006 [PubMed 16936636]). [supplied by OMIM, Mar 2008],

Product Specifications

Background

MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]) .[supplied by OMIM, Mar 2008]

UniProt

Q9NX47

Swiss Prot

Q9NX47

Reactivity

Human; Mouse; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human MARCH5. AA range:21-70

Clonality

Polyclonal

Source

Rabbit

Applications

IF; WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.

Molecular Weight

37kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

37kD

Fragment

IgG

Subcellular Location

Mitochondrion outer membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Authors show that the protein can be detected in endoplasmic reticulum (PubMed:14722266) . Authors (PubMed:16874301) show its presence only in mitochondria (PubMed:16874301) . .

Other Product Names

MARCH5; RNF153; E3 ubiquitin-protein ligase MARCH5; Membrane-associated RING finger protein 5; Membrane-associated RING-CH protein V; MARCH-V; Mitochondrial ubiquitin ligase; MITOL; RING finger protein 153