SNAT2 rabbit pAb

Enzyme regulation: Inhibited by N-methyl-D-glucamine and probably choline. function: Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1: 1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta. induction: Up-regulated upon hypertonic conditions and amino acid deprivation. miscellaneous: Depletion of SCL38A2 by siRNA prevents the recovery of cells from hypertonic stress. PTM: Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2. similarity: Belongs to the amino acid/polyamine transporter 2 family. subcellular location: Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity). Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal. tissue specificity: Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level).