Ksr2 rabbit pAb

Domain: The protein kinase domain is predicted to be catalytically inactive. function: Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. PTM: Phosphorylated on Ser-474 by MARK3. similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. similarity: Contains 1 phorbol-ester/DAG-type zinc finger. similarity: Contains 1 protein kinase domain. subunit: Interacts with MAP2K1, MAP3K8, MAPK, RAS and RAF. tissue specificity: Mainly expressed in brain and kidney.

Product Specifications

Background

Domain:The protein kinase domain is predicted to be catalytically inactive., function:Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production., PTM:Phosphorylated on Ser-474 by MARK3., similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family., similarity:Contains 1 phorbol-ester/DAG-type zinc finger., similarity:Contains 1 protein kinase domain., subunit:Interacts with MAP2K1, MAP3K8, MAPK, RAS and RAF., tissue specificity:Mainly expressed in brain and kidney.

Product Name Alternative

KSR2; Kinase suppressor of Ras 2; hKSR2

UniProt

Q6VAB6

Swiss Prot

Q6VAB6

Reactivity

Human; Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human KSR2. AA range:671-720

Target

Ksr2

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.