MLH3 rabbit pAb
This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008],
Product Specifications
Background
UniProt
Q9UHC1
Swiss Prot
Q9UHC1
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human MLH3. AA range:521-570
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Molecular Weight
164kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
164kD
Fragment
IgG
Subcellular Location
Nucleus .
Other Product Names
MLH3; DNA mismatch repair protein Mlh3; MutL protein homolog 3
Gene ID (Human)
27030
Available Sizes
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