NDR2 rabbit pAb

Catalytic activity: ATP + a protein = ADP + a phosphoprotein. Cofactor: Magnesium. enzyme regulation: Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-282. Thr-442 then undergoes calcium-dependent phosphorylation by an upstream kinase. Interactions between phosphorylated Thr-442 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38L. function: Involved in the regulation of structural processes in differentiating and mature neuronal cells. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. similarity: Contains 1 AGC-kinase C-terminal domain. similarity: Contains 1 protein kinase domain. subcellular location: Associated with the actin cytoskeleton. subunit: Homodimeric S100B binds two molecules of STK38L (By similarity). Interacts with MOB1 and MOB2. tissue specificity: Ubiquitously expressed with highest levels observed in the thymus.