DOCK 180 rabbit pAb
This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014],
Product Specifications
Background
Product Name Alternative
DOCK1; Dedicator of cytokinesis protein 1; 180 kDa protein downstream of CRK; DOCK180
UniProt
Q14185
Swiss Prot
Q14185
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human DOCK1. AA range:1661-1710
Target
DOCK 180
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
215kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
215kD
Fragment
IgG
Subcellular Location
Cytoplasm . Membrane . Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-trisphosphate. .
Other Product Names
DOCK1; Dedicator of cytokinesis protein 1; 180 kDa protein downstream of CRK; DOCK180
Gene ID (Human)
1793
Available Sizes
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