Sgo2 rabbit pAb

Function:During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis (By similarity) . May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., sequence caution:Contaminating sequence. Potential poly-A sequence., similarity:Belongs to the shugoshin family., subcellular location:In Hela cells, localizes at centromeres throughout prophase until metaphase and disappears at anaphase., subunit:Directly interacts with PPP2CA.

Nucleus . Chromosome, centromere . Chromosome, centromere, kinetochore . During meiosis I, accumulates at centromeres during diplotene, and colocalizes differentially with the cohesin subunits RAD21 and REC8 at metaphase I centromeres (By similarity) . SGO2 and RAD21 change their relative distributions during telophase I when sister-kinetochore association is lost (By similarity) . During meiosis II, it shows a striking tension-dependent redistribution within centromeres throughout chromosome congression during prometaphase II, as it does during mitosis (By similarity) . In Hela cells, localizes at centromeres throughout prophase until metaphase and disappears at anaphase (PubMed:17485487) . Centromeric localization requires the presence of BUB1 and AUKRB (PubMed:17485487) . .