IREβ rabbit pAb
Catalytic activity: ATP + a protein = ADP + a phosphoprotein. Cofactor: Magnesium. enzyme regulation: The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain. function: Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins. PTM: Autophosphorylated. similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. similarity: Contains 1 KEN domain. similarity: Contains 1 protein kinase domain.
Product Specifications
Background
Product Name Alternative
UniProt
Q76MJ5
Swiss Prot
Q76MJ5
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human ERN2. AA range:841-890
Target
IREβ
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Endoplasmic reticulum membrane ; Single-pass type I membrane protein .
Other Product Names
Gene ID (Human)
10595
Available Sizes
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