MCM6 rabbit pAb
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, i
Product Specifications
Background
Product Name Alternative
MCM6; DNA replication licensing factor MCM6; p105MCM
UniProt
Q14566
Swiss Prot
Q14566
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human MCM6. AA range:331-380
Target
MCM6
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300
Buffer
-20°C/1 year
Molecular Weight
90kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
90kD
Fragment
IgG
Subcellular Location
Nucleus . Chromosome . Binds to chromatin during G1 and detach from it during S phase. .
Other Product Names
MCM6; DNA replication licensing factor MCM6; p105MCM
Gene ID (Human)
4175
Available Sizes
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