P73 rabbit pAb
Tumor protein p73 (TP73) Homo sapiens This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011],
Product Specifications
Background
Product Name Alternative
TP73; P73; Tumor protein p73; p53-like transcription factor; p53-related protein
UniProt
O15350
Swiss Prot
O15350
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human p73 around the non-acetylation site of Lys321. AA range:281-330
Target
P73
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
70kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
70kD
Fragment
IgG
Subcellular Location
Nucleus . Cytoplasm. Accumulates in the nucleus in response to DNA damage.
Other Product Names
TP73; P73; Tumor protein p73; p53-like transcription factor; p53-related protein
Gene ID (Human)
7161
Available Sizes
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