SV2C rabbit pAb

Function: Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. PTM: N-glycosylated. similarity: Belongs to the major facilitator superfamily. subcellular location: Enriched in small synaptic vesicles and adrenal microsomes, not present in chromaffin granules. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas. subunit: Interacts with SYT1 in a calcium-dependent manner.

Product Specifications

Background

Function:Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles., PTM:N-glycosylated., similarity:Belongs to the major facilitator superfamily., subcellular location:Enriched in small synaptic vesicles and adrenal microsomes, not present in chromaffin granules. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas., subunit:Interacts with SYT1 in a calcium-dependent manner.

UniProt

Q496J9

Swiss Prot

Q496J9

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from the Internal region of human SV2C.

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.

Molecular Weight

82kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

82kD

Fragment

IgG

Subcellular Location

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein . Enriched in small synaptic vesicles and adrenal microsomes, not present in chromaffin granules. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas. .