TRADD rabbit pAb

The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008],

Product Specifications

Background

UniProt

Q15628

Swiss Prot

Q15628

Reactivity

Human; Mouse; Monkey

Immunogen

The antiserum was produced against synthesized peptide derived from human TRADD. AA range:251-300

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

Molecular Weight

34kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

34kD

Fragment

IgG

Subcellular Location

Nucleus . Cytoplasm . Cytoplasm, cytoskeleton . Shuttles between the cytoplasm and the nucleus. .

Other Product Names

TRADD; Tumor necrosis factor receptor type 1-associated DEATH domain protein; TNFR1-associated DEATH domain protein; TNFRSF1A-associated via death domain