M-RIP rabbit pAb
Function: Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. similarity: Contains 1 PH domain. similarity: Contains 2 PH domains. subcellular location: Colocalizes with F-actin. subunit: Binds F-actin through its N-terminus (By similarity). Binds RHOA, PPP1R12A/MBS and PPP1R12C/MBS85 through adjacent coiled coil domains.
Product Specifications
Background
Product Name Alternative
MPRIP; KIAA0864; MRIP; RHOIP3; Myosin phosphatase Rho-interacting protein; M-RIP; Rho-interacting protein 3; RIP3; p116Rip
UniProt
Q6WCQ1
Swiss Prot
Q6WCQ1
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from the Internal region of human M-RIP.
Target
M-RIP
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Buffer
-20°C/1 year
Molecular Weight
115kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
115kD
Fragment
IgG
Subcellular Location
Cytoplasm, cytoskeleton . Colocalizes with F-actin.
Other Product Names
MPRIP; KIAA0864; MRIP; RHOIP3; Myosin phosphatase Rho-interacting protein; M-RIP; Rho-interacting protein 3; RIP3; p116Rip
Gene ID (Human)
23164/23164
Available Sizes
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