P140Cap rabbit pAb

Function: Delays the onset of cell spreading in the early stages of cell adhesion to fibronectin. Also involved in calcium-dependent exocytosis from PC12 cells. PTM: Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands. similarity: Belongs to the p140Cap family. subcellular location: Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. subunit: Interacts with the N-terminal coiled-coil region of SNAP25 (By similarity). Interacts with BCAR1/p130Cas through its C-terminal domain.

Product Specifications

Background

Function:Delays the onset of cell spreading in the early stages of cell adhesion to fibronectin. Also involved in calcium-dependent exocytosis from PC12 cells., PTM:Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands., similarity:Belongs to the p140Cap family., subcellular location:Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions., subunit:Interacts with the N-terminal coiled-coil region of SNAP25 (By similarity) . Interacts with BCAR1/p130Cas through its C-terminal domain.

Product Name Alternative

SRCIN1; KIAA1684; P140; SRC kinase signaling inhibitor 1; SNAP-25-interacting protein; SNIP; p130Cas-associated protein; p140Cap

UniProt

Q9C0H9

Swiss Prot

Q9C0H9

Reactivity

Human; Mouse; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human SNIP. AA range:811-860

Target

P140Cap

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Buffer

-20°C/1 year

Molecular Weight

112kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

112kD

Fragment

IgG

Subcellular Location

Cytoplasm . Cytoplasm, cytoskeleton . Cell projection, axon . Cell projection, dendrite . Cell junction, synapse, presynapse . Cell junction, synapse, postsynapse . Cell junction, synapse, postsynaptic density . Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and enriched in postsynaptic density fractions. .