KIF4A rabbit pAb

Kinesin family member 4A (KIF4A) Homo sapiens This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X. [provided by RefSeq, Mar 2010],

Product Specifications

Background

Product Name Alternative

KIF4A; KIF4; Chromosome-associated kinesin KIF4A; Chromokinesin-A

UniProt

O95239

Swiss Prot

O95239

Reactivity

Human; Rat; Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human KIF4A. AA range:1171-1220

Target

KIF4A

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA; IHC

Concentration

1 mg/ml

Dilution

WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

Buffer

-20°C/1 year

Molecular Weight

140kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

140kD

Fragment

IgG

Subcellular Location

Nucleus matrix . Cytoplasm . Cytoplasm, cytoskeleton, spindle . Midbody . Chromosome . Associates with chromosomes at all stage of mitosis (PubMed:11736643, PubMed:15297875, PubMed:15625105) . Chromatin localization is dependent on iron-sulfur cluster binding (PubMed:29848660) . In anaphase, associates with the mitotic spindle midzone (PubMed:15297875) . In telophase and cytokinesis, co-localizes with CIAO2B at the spindle midzone and midbody (PubMed:29848660, PubMed:15297875) . Co-localizes with PRC1 in early mitosis and at the spindle midzone from anaphase B to telophase (PubMed:15297875, PubMed:15625105) . Does not localize to the nucleolus (PubMed:11736643) . .