IL-5 rabbit pAb

This gene encodes a Cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded Cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this Cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This Cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a Cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013],