IgA rabbit pAb

Disease: A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t (1;14) (q21;q32) that forms a FCRL4-IGHA1 fusion protein. function: Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system. PTM: 3-Hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with alpha-1-microglobulin to form heterogeneous polycyclic chromophores including hydroxanthommatin. The chromophore reacts with accessible cysteines forming non-reducible thioether cross-links with Ig alpha-1 chain C region Cys-352. similarity: Contains 3 Ig-like (immunoglobulin-like) domains. subunit: Monomeric or polymeric.