HBO1 rabbit pAb

Catalytic activity: Acetyl-CoA + histone = CoA + acetylhistone. Domain: The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L. Domain: The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction. function: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Belongs to the MYST (SAS/MOZ) family. similarity: Contains 1 C2HC-type zinc finger. subunit: Component of the HBO1 complex composed at least of ING4 or ING5, MYTS2/HBO1, EAF6, and one of PHF15, PHF16 and PHF17. Interacts with MCM2 and ORC1L. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone. tissue specificity: Ubiquitously expressed, with highest levels in testis.