Clusterin rabbit pAb

The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011]

CLU; APOJ; CLI; KUB1; AAG4; Clusterin; Aging-associated gene 4 protein; Apolipoprotein J; Apo-J; Complement cytolysis inhibitor; CLI; Complement-associated protein SP-40; 40; Ku70-binding protein 1; NA1/NA2; Testosterone-repressed prostate m

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

[Isoform 1]: Secreted . Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress. .; [Isoform 4]: Cytoplasm . Keeps cytoplasmic localization in stressed and unstressed cell. .; [Isoform 6]: Cytoplasm . Keeps cytoplasmic localization in stressed and unstressed cell. .; Nucleus . Cytoplasm . Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side . Cytoplasm, cytosol . Microsome . Endoplasmic reticulum . Mitochondrion . Mitochondrion membrane . Cytoplasm, perinuclear region . Cytoplasmic vesicle, secretory vesicle, chromaffin granule . Secreted isoforms can retrotranslocate from the secretory compartments to the cytosol upon cellular stress (PubMed:17451556) . Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated

CLU; APOJ; CLI; KUB1; AAG4; Clusterin; Aging-associated gene 4 protein; Apolipoprotein J; Apo-J; Complement cytolysis inhibitor; CLI; Complement-associated protein SP-40; 40; Ku70-binding protein 1; NA1/NA2; Testosterone-repressed prostate m