BRAF35 rabbit pAb

Function: Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters. sequence Caution: Translation N-terminally extended. similarity: Contains 1 HMG box DNA-binding domain. subcellular location: Localized to condensed chromosomes in mitosis in conjunction with BRCA2. subunit: Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, AOF2/LSD1, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with the BRCA2 tumor suppressor protein. tissue specificity: Ubiquitously expressed in adult tissues.

Product Specifications

Background

Function:Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters., sequence caution:Translation N-terminally extended., similarity:Contains 1 HMG box DNA-binding domain., subcellular location:Localized to condensed chromosomes in mitosis in conjunction with BRCA2., subunit:Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, AOF2/LSD1, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with the BRCA2 tumor suppressor protein., tissue specificity:Ubiquitously expressed in adult tissues.

UniProt

Q9P0W2

Swiss Prot

Q9P0W2

Reactivity

Human; Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human HMG20B. AA range:1-50

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Molecular Weight

36kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

36kD

Fragment

IgG

Subcellular Location

Nucleus. Chromosome. Localized to condensed chromosomes in mitosis in conjunction with BRCA2.

Other Product Names

HMG20B; BRAF35; HMGX2; HMGXB2; SMARCE1R; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related; SMARCE1-related protein; BRCA2-associated factor 35; HMG box-containing protein 20B; HMG domain-