FRS2 (phospho Tyr436) rabbit pAb
Function: Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. PTM: Phosphorylated on tyrosine residues upon stimulation by NGF. PTM: Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination. sequence Caution: Translated as stop. similarity: Contains 1 IRS-type PTB domain. subcellular location: Cytoplasmic, membrane-bound. subunit: Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11. tissue specificity: Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
Product Specifications
Background
Synonyms
FRS2; Fibroblast growth factor receptor substrate 2; FGFR substrate 2; FGFR-signaling adaptor SNT; Suc1-associated neurotrophic factor target 1; SNT-1
Gene ID
10818
UniProt
Q8WU20
Cellular Locus
Endomembrane system. Cytoplasmic, membrane-bound.
Host
Rabbit
Species Reactivity
Human,Mouse,Monkey
Reactivity
Human; Mouse; Monkey
Immunogen
The antiserum was produced against synthesized peptide derived from human FRS2 around the phosphorylation site of Tyr436. AA range:402-451
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, IHC, IF, ELISA
Validated Applications
WB,IHC,IF,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
65kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES1496-1.pdf
Observed Molecular Weight
65 kD
Subcellular Location
Endomembrane system. Cytoplasmic, membrane-bound.
Other Product Names
FRS2; Fibroblast growth factor receptor substrate 2; FGFR substrate 2; FGFR-signaling adaptor SNT; Suc1-associated neurotrophic factor target 1; SNT-1
Gene ID (Human)
10818
SwissProt (Human)
Q8WU20
Available Sizes
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