EIF2α (phospho Ser51) rabbit pAb
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al. 1987 [PubMed 2948954]). [supplied by OMIM, Feb 2010],
Product Specifications
Background
Product Name Alternative
UniProt
P05198
Swiss Prot
P05198
Reactivity
Human; Mouse; Rat; Dog; Pig; Fish
Immunogen
The antiserum was produced against synthesized peptide derived from human eIF2 alpha around the phosphorylation site of Ser51. AA range:21-70
Target
EIF2α
Clonality
Polyclonal
Source
Rabbit
Applications
IF; WB; IHC; ELISA
Concentration
1 mg/ml
Dilution
IF: 1:50-200 Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
38kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
38kD
Fragment
IgG
Subcellular Location
Cytoplasm, Stress granule . Colocalizes with NANOS3 in the stress granules. .
Other Product Names
Gene ID (Human)
1965
Available Sizes
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